Material Safety Data Sheet
1-Methyl-2-pyrrolidinone
ACC# 08690
Section 1 - Chemical Product and Company Identification |
MSDS Name: 1-Methyl-2-pyrrolidinone
Catalog Numbers:
AC127630010, AC127630025, AC222080025, AC222085000, AC326930010,
AC326931000, AC326932500, AC354890025, AC354900025, AC364380010,
AC364380025, AC364381000, AC368450010, AC368450025, AC368451000,
AC610411000, BP1172-4, BP11724LC, BP1172N119, BP2619-100, NC9749337,
O3688-4
Synonyms:
NMP; N-Methylpyrrolidone; N-Methylpyrrolidinone;
N-Methyl-2-pyrrolidone; N-Methyl-2-pyrrolidinone; M-Pyrol;
1-Methyl-2-pyrrolidone; solvent in paint strippers.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
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CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
872-50-4 |
1-Methyl-2-pyrrolidinone |
99 | 212-828-1 |
Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: clear colorless liquid. Flash Point: 91 deg C.
Warning! Causes eye, skin, and respiratory tract
irritation. May cause harm to the unborn child.
Combustible liquid and vapor. May be harmful if
swallowed, inhaled, or absorbed through the skin. Light sensitive.
Hygroscopic (absorbs moisture from the air).
Target Organs: Respiratory system, eyes, skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause temporary corneal clouding.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Not expected to cause an allergic skin reaction.
Because of the high permeability rate of N-methylpyrrolidone in human
skin, prolonged exposures should be avoided.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea.
Inhalation:
Causes respiratory tract irritation. May cause headache. Material
has a very low vapor pressure and inhalation exposures are not
expected unless material is heated or misted.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Adverse
reproductive effects have been reported in animals.
Testicular effects in rats were noted after repeated, high-dose oral
and inhalation exposures.(BASF)Human occupational exposure has been
associated with chronic eye irritation, headaches, and irritant
contact dermatitis. Airborne concentrations of 49 to 83 ppm are
intolerable.(REPROTEXT)
Section 4 - First Aid Measures
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Eyes:
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious
person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Combustible
liquid and vapor.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: 91 deg C ( 195.80 deg F)
Autoignition Temperature: 245 deg C ( 473.00 deg F)
Explosion Limits, Lower:1.3%
Upper: 9.5%
NFPA Rating:
(estimated) Health: 2; Flammability: 2; Instability: 0
Section 6 - Accidental Release Measures
|
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Provide ventilation.
Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Avoid contact with
eyes, skin, and clothing. Keep away from heat and flame. Avoid
breathing vapor or mist.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Keep under a nitrogen blanket.
Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
1-Methyl-2-pyrrolidinone
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
1-Methyl-2-pyrrolidinone:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: clear colorless
Odor: amine-like - mild odor
pH: 8.5-10.0 (100 g/l H2O)
Vapor Pressure: 0.342 mm Hg @ 25 deg C
Vapor Density: 3.4 (air=1)
Evaporation Rate:Not available.
Viscosity: 1.65 cps @ 25 deg C
Boiling Point: 202 deg C @ 760 mm Hg
Freezing/Melting Point:-24 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:1.030
Molecular Formula:C5H9NO
Molecular Weight:99.13
Section 10 - Stability and Reactivity
|
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
Light, ignition sources, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
|
RTECS#:
CAS# 872-50-4:
UY5790000
LD50/LC50:
CAS# 872-50-4:
Draize test,
rabbit, eye: 100 mg Moderate;
Oral, mouse: LD50 = 5130 mg/kg;
Oral, rat: LD50 = 3914 mg/kg;
Skin, rabbit: LD50 = 8 gm/kg;
.
Sensitization test (guinea pig): negative.
test (humans):
negative.(Merck)
Carcinogenicity:
CAS# 872-50-4:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
Proposition 65 maximum allowable dose level for
developmental toxicity for N-methylpyrrolidone is 3200
ug/day for the inhalation route and 17,000 ug/day for the
dermal route.
Reproductive Effects:
See actual entry in RTECS for complete information.
Mutagenicity:
See actual entry in RTECS for complete information.
Neurotoxicity:
No data available.
Other Studies:
Section 12 - Ecological Information
|
Ecotoxicity:
Daphnia: Daphnia: 4897 mg/l; 48 h; EC50Fish: Gold orfe: 4000
mg/l; 96 h; LC50Bacteria: >9000 mg/l; 48 h; EC50Algae: >500
mg/l; 72 h; IC50
log Pow = -0.46 (25°C)BOD5 = 1100 mg/l.COD = 1600 mg/l.
Environmental:
No information available.
Physical:
No information available.
Other:
Biodegradable.
Section 13 - Disposal Considerations
|
Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
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US DOT |
Canada TDG |
Shipping Name: |
Not regulated |
Not Regulated |
Hazard Class: |
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UN Number: |
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Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 872-50-4 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
CAS# 872-50-4: Test for Health Effects
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 872-50-4: immediate, delayed, fire.
Section 313
This material contains
1-Methyl-2-pyrrolidinone (CAS# 872-50-4, 99%),which is subject to
the reporting requirements of Section 313 of SARA Title III and 40
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 872-50-4 can be found on the
following state right to know lists: Pennsylvania, Minnesota,
Massachusetts.
California Prop 65
WARNING: This product contains 1-Methyl-2-pyrrolidinone, a chemical
known to the state of California to cause developmental reproductive
toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system and skin.
R 61 May cause harm to the unborn child.
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 53 Avoid exposure - obtain special instructions before use.
WGK (Water Danger/Protection)
CAS# 872-50-4: 1
Canada - DSL/NDSL
CAS# 872-50-4 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B3, D2A, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
|
MSDS Creation Date: 6/10/2003
Revision #2 Date: 3/29/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.