Material Safety Data Sheet
1-Butanol, reagent ACS, 99.4%
ACC# 01053
Section 1 - Chemical Product and Company Identification |
MSDS Name: 1-Butanol, reagent ACS, 99.4%
Catalog Numbers:
AC423490000, AC423490010, AC423490040, AC423492000, AC423495000
Synonyms:
n-Butanol; 1-Butanol; n-Butyl alcohol; 1-Butyl alcohol; Butyl
hydroxide; 1-Hydroxybutane; Methylolpropane; n-Propylcarbinol;
Propylmethanol; Butyric alcohol.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
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CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
71-36-3 | n-Butyl alcohol |
>99.4 | 200-751-6 |
Hazard Symbols: XN
Risk Phrases: 10 22 37/38 41 67
Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: colorless liquid. Flash Point: 35 deg C.
Warning! Flammable liquid and
vapor. May be harmful if swallowed. May cause central
nervous system depression. Aspiration hazard if swallowed. Can enter
lungs and cause damage. Causes respiratory tract irritation. Causes
severe eye irritation. Causes skin irritation. Breathing vapors may
cause drowsiness and dizziness.
Target Organs: Central nervous system,
respiratory system, eyes, skin.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause corneal edema and
inflammation. May cause lacrimation (tearing), blurred vision, and
photophobia.
Vapors appear to cause a special vacuolar keratopathy in humans.
Skin:
Causes skin irritation. Skin absorption is slight. Repeated or
prolonged exposure may cause drying and cracking of the skin.
Although n-butanol can enter the circulation after topical application
, the absorbed dose is insignificant compared to that from other route
s.
Ingestion:
May cause central nervous system depression, characterized by
excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and
possible death due to respiratory failure. Aspiration of material
into the lungs may cause chemical pneumonitis, which may be fatal.
May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May cause cardiovascular
disturbances, hearing abnormalities, central nervous system
depression, muscle weakness, and possible death due to respiratory
failure. May be absorbed through the lungs.
Chronic:
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause damage to the auditory nerve (some hearing
loss) and vestibular injury. Animal evidence suggests that
fetotoxicity and teratogenicity may be observed at doses that also
cause harmful effects in the mothers. The systemic toxicity of
n-butanol is low, although it may potentiate the hepatic (liver)
toxicity of other inhaled compounds, such as carbon tetrachloride.
Section 4 - First Aid Measures
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Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical
personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Alcoholic beverage consumption may enhance the toxic effects of this
substance. Persons with liver, kidney, or central nervous system
diseases may be at increased risk from exposure to this product.
Butanol is especially toxic if aspirated. Treat symptomatically and
supportively.
Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Use water spray to keep fire-exposed containers
cool. Flammable liquid and vapor. Vapors are heavier than air and may
travel to a source of ignition and flash back. Vapors can spread
along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Flash Point: 35 deg C ( 95.00 deg F)
Autoignition Temperature: 343 deg C ( 649.40 deg F)
Explosion Limits, Lower:1.4 vol %
Upper: 11.2 vol %
NFPA Rating:
(estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Provide ventilation. Use only non-sparking tools and equipment.
Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Avoid
contact with eyes, skin, and clothing. Empty containers retain
product residue, (liquid and/or vapor), and can be dangerous. Do not
ingest or inhale. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open
flames. Use only with adequate ventilation. Keep away from heat,
sparks and flame.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a cool, dry, well-ventilated area away from
incompatible substances.
Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use process enclosure, local exhaust ventilation, or other
engineering controls to control airborne levels below recommended
exposure limits. Facilities storing or utilizing this material should
be equipped with an eyewash facility and a safety shower.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
n-Butyl alcohol | 20 ppm TWA |
1400 ppm IDLH | 100 ppm TWA; 300 mg/m3 TWA |
OSHA Vacated PELs:
n-Butyl alcohol:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: colorless
Odor: vinous or wine-like
pH: Not available.
Vapor Pressure: 6.7 mm Hg @ 25 deg C
Vapor Density: 2.6 (Air=1)
Evaporation Rate:0.46 (Butyl acetate=1)
Viscosity: 2.94 cP at 20 deg C
Boiling Point: 116 deg C
Freezing/Melting Point:-89.5 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble.
Specific Gravity/Density:0.8100 (Water=1)
Molecular Formula:C4H10O
Molecular Weight:74.12
Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, alkali metals, halogens.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
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RTECS#:
CAS# 71-36-3: EO1400000
LD50/LC50:
CAS# 71-36-3:
Draize test, rabbit, eye: 2 mg Severe;
Draize
test, rabbit, eye: 2 mg/24H Severe;
Draize test, rabbit, skin:
405 mg/24H Moderate;
Draize test, rabbit, skin: 20 mg/24H
Moderate;
Inhalation, rat: LC50 = 24000 mg/m3/4H;
Inhalation,
rat: LC50 = 8000 ppm/4H;
Oral, mouse: LD50 = 100 mg/kg;
Oral,
rabbit: LD50 = 3400 mg/kg;
Oral, rabbit: LD50 = 3484 mg/kg;
Oral, rat: LD50 = 800 mg/kg;
Oral, rat: LD50 = 790 mg/kg;
Skin, rabbit: LD50 = 3400 mg/kg;
Carcinogenicity:
CAS# 71-36-3:
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
No data available.
Teratogenicity:
See actual entry in RTECS for complete information.
Reproductive Effects:
See actual entry in RTECS for complete information.
Neurotoxicity:
No information available.
Mutagenicity:
See actual entry in RTECS for complete information.
Other Studies:
No data available.
Section 12 - Ecological Information
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Ecotoxicity:
Fish: Fathead Minnow: LC50 = 1510-1730 mg/L; 96 Hr; Static bioassay
at 24.7°C (pH 7.64)
flea Daphnia: EC50 = 1980-1983 mg/L; 48
Hr; Unspecified
ria: Phytobacterium phosphoreum: EC50 =
2817-3710 mg/L; 5,30 min; Microtox test
Release of n-butanol to soil may result in volatilization from the
soil surface and biodegradation is expected to be significant.
n-Butanol should not bind strongly to soil and so is expected to
leach into groundwater. Release of n-butanol to water is expected to
result in biodegradation and in volatilization from the water
surface. Photooxidation by hydroxyl radicals is expected to be slow.
Environmental:
When released to soil, substance is expected to biodegrade, leach to
ground water or volatilize. In water, substance is expected to
biodegrade or volatilize. Bioconcentration potential is predicted to
be low. Soil Mobility: Substance is moderately to highly mobile (log
octanol/ water partition coefficient=0.88).
Physical:
Substance reacts in air with hydroxyl radicals (half-life=2.3 days).
Other:
None.
Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 71-36-3: waste number
U031 (Ignitable waste).
Section 14 - Transport Information
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US DOT |
IATA |
RID/ADR |
IMO |
Canada TDG |
Shipping Name: |
BUTANOLS |
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No information available. |
Hazard Class: |
3 |
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UN Number: |
UN1120 |
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Packing Group: |
III |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 71-36-3 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
CAS# 71-36-3: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 71-36-3: acute, flammable.
Section 313
This material contains n-Butyl alcohol (CAS# 71-36-3, 99 4%),which is
subject to the reporting requirements of Section 313 of SARA Title
III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
CAS# 71-36-3 can be found on the following state right to know
lists: California, New Jersey, Pennsylvania, Minnesota,
Massachusetts.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 10 Flammable.
R 22 Harmful if swallowed.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 67 Vapors may cause drowsiness and dizziness.
Safety Phrases:
S 13 Keep away from food, drink and animal feeding
stuffs.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
S 46 If swallowed, seek medical advice immediately
and show this container or label.
S 7/9 Keep container tightly closed and in a
well-ventilated place.
WGK (Water Danger/Protection)
CAS# 71-36-3: 1
Canada - DSL/NDSL
CAS# 71-36-3 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
Canadian Ingredient Disclosure List
CAS# 71-36-3 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 71-36-3: OEL-AUSTRALIA:TWA 50 ppm (150 mg/m3);Skin OEL-AUSTRIA
:TWA 100 ppm (300 mg/m3) OEL-BELGIUM:STEL 50 ppm (152 mg/m3);Skin OE
L-CZECHOSLOVAKIA:TWA 100 mg/m3;STEL 200 mg/m3 OEL-DENMARK:STEL 50 ppm
(150 mg/m3);Skin OEL-FINLAND:TWA 50 ppm (150 mg/m3);STEL 75 ppm (225
mg/m3);Skin OEL-FRANCE:STEL 50 ppm (150 mg/m3) OEL-GERMANY:TWA 100
ppm (300 mg/m3) OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin OEL-IN
DIA:TWA 50 ppm (150 mg/m3);Skin OEL-JAPAN:STEL 50 ppm (150 mg/m3);Ski
n OEL-THE NETHERLANDS:TWA 50 ppm (150 mg/m3);Skin OEL-THE PHILIPPINE
S:TWA 100 ppm (300 mg/m3) OEL-RUSSIA:STEL 50 ppm (10 mg/m3) OEL-SWED
EN:TWA 15 ppm (45 mg/m3);STEL 30 ppm (90 mg/m3);Skin OEL-SWITZERLAND:
TWA 50 ppm (150 mg/m3);STEL 100 ppm;Skin OEL-TURKEY:TWA 100 ppm (300
mg/m3) OEL-UNITED KINGDOM:TWA 50 ppm (150 mg/m3);STEL 50 ppm;Skin OE
L IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEA
LAND, SINGAPORE, VIETNAM check ACGI TLV
Section 16 - Additional Information
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MSDS Creation Date: 6/10/1999
Revision #5 Date: 10/28/2002
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.