SIGMA CHEMICAL CO -- THROMBIN FROM HUMAN PLASMA, T8885  -- 6505-00N093117
<pre>=====================  Product Identification  =====================

Product ID:THROMBIN FROM HUMAN PLASMA, T8885
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093117
Status Code:A
=== Responsible Party ===
Company Name:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:THROMBIN
CAS:9002-04-4
RTECS #:XO8950000
= Wt:100.
Other REC Limits:N/K 
OSHA PEL:N/K 
OSHA STEL:N/K 
ACGIH TLV:N/K 
ACGIH STEL:N/K 

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF ENTERS
    BLOODSTREAM. MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN
    ABSORPTION. MAY CAUSE EYE AND SKIN IRRITATION. MATERIAL MAY BE
    IRRITATING TO MUCOUS MEMBRANES AND UPPER RESP IRATORY TRACT.
    PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN
    CERTAIN SENSITIVE INDIVIDUALS. HUMAN SOURCE MATERIAL. INVOLVED IN
    CLOTTING. TARGET ORGANS: VASCULAR SYSTEM. TO THE BEST OF 
    MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL
    PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
    SHOES. ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE
    EYELIDS WITH  FINGERS. INHALATION: REMOVE TO FRESH AIR. IF NOT
    BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT,
    GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON
    IS CONSCIOUS. CALL	A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
    REUSE.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:NON-COMBUSTIBLE. USE EXTINGUISHING MEDIA
    APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS AND FULL PROTECTIVE EQUIPMENT .

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
    SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED
    MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND
    REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP
    IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
    ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. DO NOT
    USE IF SKIN IS CUT OR SCRATCHED. POSSIBLE SENSITIZER. KEEP TIGHTLY
    CLOSED. STORE IN A COOL DRY  PLACE. POTENTIALLY BIOHAZARDOUS
    MATERIAL.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
    DESIGN CRITERIA . PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
    KNOWN.

===================  Toxicological Information	===================

Toxicological Information:RTECS # XO8950000, THROMBIN. TOXICITY DATA:
    IPR-RAT LD50: >40 ML/KG; OYYAA2 28, 329, 1984. SCU-RAT LD50: >40
    ML/KG; OYYAA2 28, 329, 1984. SKN-MUS LD50: >3 GM/KG; YACHDS 1, 272,
    1973. IPR-MUS LD50: >50  ML/KG; OYYAA2 28, 329, 1984. SCU-MUS LD50:
    >50 ML/KG; OYYAA2 28, 329, 1984. IVN-MUS LD50: 7771 UG/KG; YACHDS
    16, 669, 1988. TARGET ORGAN DATA: BEHAVIORAL (ALTERED SLEEP TIME);
    LUNGS, THORAX OR RESPIR ATION (OTHER CHANGES); KIDNEYS, URETER,
    BLADDER (OTHER CHANGES). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF
    CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL
    ENTRY IN RTECS FOR COMPLETE I NFORMATION.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSAL SHOULD BE MADE IN ACCORDANCE WITH
    EXISTING DISPOSAL PRACTICES EMPLOYED FOR INFECTIOUS WASTE AT YOUR
    INSTITUTION. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL
    REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS:
    OEL=MAK. NOES 1983: HZD X3641; NIS 3; TNF 339; NOS 7; TNE 7383; TFE
    5915. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY.
State Regulatory Information:

=======================  Other Information  =======================

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