Material Safety Data Sheet
Pyridine

ACC# 04395
Section 1 - Chemical Product and Company Identification
MSDS Name: Pyridine
Catalog Numbers: AC131780000, AC131780010, AC131780025, AC131780500, AC290860000, AC339420000 AC339420000, AC339420010, AC339421000, AC364420000, AC364420010, AC364421000 AC364421000, AC386560000, AC386560010, AC386560250, AC386562500, AC418530000 AC418530000, AC418530010, AC418532500, AC418540000, AC418545000
Synonyms:
Company Identification:
              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
110-86-1Pyridine >99% 203-809-9

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Not available. Appearance: colorless clear liquid. Flash Point: 17 deg C.
Not available.
Target Organs: Kidneys, heart, central nervous system, liver, bone marrow.


Potential Health Effects
Eye: Contact with eyes may cause severe irritation, and possible eye burns.
Skin: Causes skin irritation. Harmful if absorbed through the skin. Causes symptoms similar to those of inhalation.
Ingestion: Harmful if swallowed. May cause central nervous system depression, kidney damage, and liver damage. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those for inhalation exposure.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. Prolonged exposure may result in dizziness and general weakness.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage.

Section 4 - First Aid Measures


Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire.
Extinguishing Media: Use water spray to cool fire-exposed containers. Use foam, dry chemical, or carbon dioxide. Water may be ineffective.
Flash Point: 17 deg C ( 62.60 deg F)
Autoignition Temperature: 482 deg C ( 899.60 deg F)
Explosion Limits, Lower:1.8 Vol %
Upper: 12.4 Vol %
NFPA Rating: (estimated) Health: 3; Flammability: 3; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool.

Section 7 - Handling and Storage


Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Pyridine 1 ppm TWA 5 ppm TWA; 15 mg/m3 TWA 1000 ppm IDLH 5 ppm TWA; 15 mg/m3 TWA

OSHA Vacated PELs: Pyridine: 5 ppm TWA; 15 mg/m3 TWA
Personal Protective Equipment
Eyes: Not available.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Clear liquid
Appearance: colorless
Odor: fish-like
pH: 8.5 (15 g/l aq. solution)
Vapor Pressure: 20mbar @20 deg C
Vapor Density: 2.73 (Air=1)
Evaporation Rate:Not available.
Viscosity: 0.95 mPa s @20 deg C
Boiling Point: 115 - 116 deg C @760mmHg
Freezing/Melting Point:-42 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:0.978
Molecular Formula:C5H5N
Molecular Weight:79.1

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials: Oxidizing agents, acids, acid chlorides, chloroformates, formamide, iodine, sulfur trioxide.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - Toxicological Information


RTECS#:      
CAS# 110-86-1: UR8400000
LD50/LC50:
CAS# 110-86-1:
     Dermal, guinea pig: LD50 = 1 gm/kg;
     Draize test, rabbit, skin: 500 mg/24H Mild;
     Inhalation, rat: LC50 = 28500 mg/m3/1H;
     Oral, mouse: LD50 = 1500 mg/kg;
     Oral, rat: LD50 = 891 mg/kg;
     Skin, rabbit: LD50 = 1121 mg/kg;
Carcinogenicity:
CAS# 110-86-1:


Epidemiology: A low number of injection-site tumors were found in rats that received subcutaneous injections of pyridine at doses up to 100 mg/kg/day, twice weekly for a year; however, there were no indications of real oncogenic potential.
Teratogenicity: No studies in mammals were found. Tests in the hydra did not suggest the material should be tested in mammals.
Reproductive Effects: No data available.
Mutagenicity: Pyridine's mutagenicity potential is equivocal. It was reported to be both positive and negative in Salmonella typhimurium strains. It was not mutagenic in tests for chromosome aberrations, but did give weak positive results in tests that detect sister chromatid exchanges.
Neurotoxicity: No data available.
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: No data available. Log POW = 0.8 (calc.)
Environmental: No information available.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 110-86-1: waste number U196.

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: PYRIDINE PYRIDINE
Hazard Class: 3 3
UN Number: UN1282 UN1282
Packing Group: II II
Additional Info:FLASHPOINT 17C

Section 15 - Regulatory Information

US FEDERAL
TSCA
     CAS# 110-86-1 is listed on the TSCA inventory.
Health & Safety Reporting List
     CAS# 110-86-1: Effective 10/4/82, Sunset 10/4/92
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 110-86-1: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 110-86-1: acute, chronic, flammable.
Section 313
     This material contains Pyridine (CAS# 110-86-1, >99%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 110-86-1 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.

California Prop 65
The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act:
WARNING: This product contains Pyridine, a chemical known to the state of California to cause cancer.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN F
Risk Phrases:
     R 11 Highly flammable.
     R 20/21/22 Harmful by inhalation, in contact with skin and if
     swallowed.

Safety Phrases:
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 28A After contact with skin, wash immediately with plenty of
     water.

WGK (Water Danger/Protection)
     CAS# 110-86-1: 2
Canada - DSL/NDSL
     CAS# 110-86-1 is listed on Canada's DSL List.
Canada - WHMIS
     This product does not have a WHMIS classification.
Canadian Ingredient Disclosure List
     CAS# 110-86-1 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 1/16/2002
Revision #1 Date: 6/14/2005

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.