SIGMA-ALDRICH CHEMICAL CO -- KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETICUS, K4000  -- 6810-00N091818
<pre>=====================  Product Identification  =====================

Product ID:KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETICUS, K4000
MSDS Date:03/16/1999
FSC:6810
NIIN:00N091818
Status Code:A
=== Responsible Party ===
Company Name:SIGMA-ALDRICH CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
Resp. Party Other MSDS Num.:C18H36N4011
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:KANAMYCIN, SULFATE (1:1) (SALT); (MF:C*18H*36N*4O*11)
CAS:25389-94-0
RTECS #:NZ3225030

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:LD50:(ORAL,RAT) >4 GM/KG & TOX INFO
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
    INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE
    SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND
    UPPER RESPIRATORY TRACT. PROL ONGED OR REPEATED EXPOSURE MAY CAUSE
    ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS.
    AMINOGLYCOSIDES ARE ASSOCIATED WITH SIGNIFICANT NEPHROTOXICITY
    AND/OR OTOTOXICITY. CHRONIC: MAY CAUSE CONGENIT AL MALFORMATION IN
    THE FETUS. TARGET ORGAN(S): KIDNEYS, EARS. TO THE BEST OF MFR'S
    KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE
    NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
    CONSCIOUS. CALL MD. SKIN: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
    AT LEAST 15 MINUTES REMOVE CONTAMINATED CLOTHING AND SHOES. CALL
    MD. INHALATIO N: REMOVE TO FRESH AIR. IF BREATHING BECOMES
    DIFFICULT, CALL MD. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
    AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS
    WITH FINGERS. CALL MD .

=====================  Fire Fighting Measures  =====================

Extinguishing Media:NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE
    TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
    SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
    PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
    COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
    EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
    KEEP TIGHTLY CLOSED. STORE IN A COOL, DRY PLACE.
Other Precautions:TOXIC. MAY CAUSE HARM TO THE UNBORN CHILD. IN CASE OF
    ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY
    (SHOW LABEL WHERE POSSIBLE).

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
    FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
    WEAR SUITABLE OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Solubility in Water:SOLUBLE
Appearance and Odor:SOLID.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
    CARBON DIOXIDE, NITROGEN OXIDES.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

===================  Toxicological Information	===================

Toxicological Information:LD50:(ORAL,RAT) >4 GM/KG - JJANAX
    28,415,1975; LD50:(IPR,RAT) 3200 MG/KG - JJANAX 28,415,1975;
    LD50:(SCU,RAT) 1700 MG/KG - ARZNAD 12,597,1962; LD50:(IVN,RAT) 225
    MG/KG - JJANAX 28,415,1975; LD50:(IMS, RAT) >4 GM/KG - JJANAX
    28,415,1975; LD50:(ORAL,MUS) 17,500 MG/KG - NIIRDN 6,173,1982;
    LD50:(IPR,MUS) 1353 MG/KG - AACHAX -,138,1963; LD50:(SCU,MUS) 1100
    MG/KG - ANTBAL 29,851,1984; LD50:(IVN,MUS) 240  MG/KG - NIIRDN
    6,173,1982; LD50:(IMS,MUS) 1190 MG/KG - NIIRDN 6,173,1982;
    LD50:(ORAL,RBT) >3 GM/KG - JJANAX 28,415,1975; LD50:(SCU,RBT) >3
    GM/KG - JJANAX 28,415,1975; LD50:(IVN,RBT) 550 MG/KG - JJANAX 
    28,415,1975; (OTHER INFO)

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:REVIEWS, STANDARDS AND REGULATIONS:
    OEL=MAK. NOES 1983; HZD X4729; NIS 2; TNF 320; NOS 6; TNE 11433;
    TFE 8118.  EUROPEAN INFO:  TOXIC;  R61 MAY CAUSE HARM TO THE UNBORN
    CHILD, S45 IN CASE OF ACCIDENT  OR IF YOU FEEL UNWELL, SEEK MED
    ADVICE IMMED (SHOW LABE WHERE POSS), S36/37/39 WEAR SUITABLE PROT
    CLTHG, GLOVES, & EYE/FACE PROT.
State Regulatory Information:CALIFORNIA PROPOSITION 65. THIS PRODUCT IS
    OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
    DEVELOPMENTAL TOXICITY.

=======================  Other Information  =======================

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