SIGMA CHEMICAL CO -- PAPAIN LYOPHILIZED, P4762  -- 6505-00N093124
<pre>=====================  Product Identification  =====================

Product ID:PAPAIN LYOPHILIZED, P4762
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093124
Status Code:A
=== Responsible Party ===
Company Name:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:PAPAIN
CAS:9001-73-4
RTECS #:RU4950000
= Wt:100.
Other REC Limits:N/K 
OSHA PEL:N/K 
OSHA STEL:N/K 
ACGIH TLV:N/K 
ACGIH STEL:N/K 

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
    INGESTION, OR SKIN ABSORPTION. PROLONGED OR REPEATED EXPOSURE MAY
    CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. EXPOSURE
    CAN CAUSE ASTHMA, SKIN ERUPTI ONS, EMPHYSEMA, ANAPHYLACTIC SHOCK,
    AND PROTEOLYTIC ACTION.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
    CONSCIOUS. CALL A PHYSICIAN. SKIN: FLUSH WITH COPIOUS AMOUNTS OF
    WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A P HYSICIAN. INHALATION: REMOVE TO FRESH AIR. IF
    BREATHING BECOMES DIFFICULT, CALL A PHYSICIAN. EYES: FLUSH WITH
    COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE
    FLUSHING BY SEPARATING T HE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS AND FULL PROTECTIVE EQUIPMENT .

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
    SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
    PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
    COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID PROLONGED OR REPEATED EXPOSURE.
    AVOID BREATHING DUST. KEEP CONTAINER CLOSED. USE WITH ADEQUATE
    VENTILATION.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
    DESIGN CRITERIA . PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Solubility in Water:SOLUBLE
Appearance and Odor:TAN COARSE PARTICLES.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:PROTECT FROM LIGHT.
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
    KNOWN.

===================  Toxicological Information	===================

Toxicological Information:RTECS # RU4950000, PAPAIN. TOXICITY DATA:
    ORL-RAT LD50: >4 GM/KG; AIPTAK 159, 126, 1966. ORL-MUS LD50: 12500
    MG/KG; NYKZAU 51, 27, 1955. TARGET ORGAN DATA: GI (CHANGES IN
    STRUCTURE/FUNCTION OF ESOPHAG US); EFFECTS ON FERTILITY
    (POST-IMPLANTATION MORTALITY); EFFECTS ON EMBRYO/FETUS (FETAL
    DEATH); SPECIFIC DEVELOPMENTAL ABNORMALITIES (CNS, MUSCULOSKELETAL
    SYSTEM, HEPATOBILIARY SYSTEM, UROGENITAL SYST EM, HOMEOSTASIS,
    OTHER DEVELOPMENTAL ABNORMALITIES); EFFECTS OF NEWBORN
    (WEANING/LACTATION INDEX). ONLY SELECTED REGISTRY OF TOXIC EFFECTS
    OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE AC TUAL
    ENTRY IN RTECS FOR COMPLETE INFO.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:EUROPEAN INFORMATION: HARMFUL. R
    36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. R 42:
    MAY CAUSE SENSITIZATION BY INHALATION. S 22: DO NOT BREATHE DUST. S
    24: AVOID CONTACT WITH SKIN. S 26:	IN CASE OF CONTACT WITH EYES,
    RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. S
    36/37: WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES. REVIEWS,
    STANDARDS, AND REGULATIONS: OEL=MAK. NOHS  1974: HZD 80474; NIS 28;
    TNF 3537; NOS 77; TNE 46199. NOES 1983: HZD 80474; NIS 6; TNF 431;
    NOS 15;  TNE 8042, TFE 3088. EPA TSCA SECTION 8 (B) CHEMICAL
    INVENTORY.
State Regulatory Information:

=======================  Other Information  =======================

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