SIGMA CHEMICAL CO -- B-ESTRADIOL, E8875  -- 6810-00N064480
<pre>=====================  Product Identification  =====================

Product ID:B-ESTRADIOL, E8875
MSDS Date:02/22/1990
FSC:6810
NIIN:00N064480
=== Responsible Party ===
Company Name:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:800-325-3010
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:ESTRADIOL; (B-ESTRADIOL)
CAS:50-28-2
RTECS #:KG2975000
OSHA PEL:N/K 
ACGIH TLV:N/K 

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:NONE SPECIFIED BY MANUFACTURER.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:YES    IARC:NO	 OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED
    OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. CHRONIC:
    CARCINOGEN. MAY CAUSE CONGENITAL MALFORMATION IN THE FETUS. MAY
    ALTER GENETIC MATERIAL. TO THE BEST OF MAN UFACTURER'S KNOWLEDGE,
    THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN
    THOROUGHLY INVESTIGATED.
Explanation of Carcinogenicity:ESTRADIOL: NTP 7TH ANNUAL REPORT ON
    CARCINOGENS, 1994: ANTICIPATED TO BE CARCINOGEN. ANIMAL: KIDNEYS,
    SKIN.
Effects of Overexposure:SEE HEATLH HAZARDS.
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

=======================  First Aid Measures  =======================

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND
    SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
    ARTIFICIAL RES PIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    CALL MD. INGESTION: CALL MD IMMEDIATELY . DISCARD CONTAMINATED
    CLOTHING AND SHOES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:USE WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL
    POWDER, ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA & FULL
    PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH/MSHA APPROVED SCBA,
    RUBBER BOOTS & HEAVY RUBBER GLOVES. WEAR DISPOSABLE COVERALLS &
    DISCARD THEM AFTER USE. SWEEP UP, PLACE IN A BAG & HOLD FOR
    DISPOSAL. VENTILATE AREA & WAS H SPILL SITE AFTER MATERIAL PICK-UP
    IS COMPLETE.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:DO NOT BREATHE DUST. AVOID ALL
    CONTACT. CARCINOGEN. TERATOGEN. MUTAGEN. KEEP TIGHTLY CLOSED. STORE
    IN A COOL DRY PLACE.
Other Precautions:NONE SPECIFIED BY MANUFACTURER.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WEAR APPROPRIATE NIOSH/MSHA APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPRVD CHEM WORKERS GOGGS .
Other Protective Equipment:WEAR PROTECTIVE CLOTHING. EMERGENCY EYEWASH
    & DELUGE SHOWER MEETING ANSI DESIGN CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
NONE SPECIFIED BY MANUFACTURER.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
    CARBON DIOXIDE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE, AND LOCAL
    LAWS.

 Disclaimer (provided with this information by the compiling agencies):
 This information is formulated for use by elements of the Department
 of Defense.  The United States of America in no manner whatsoever,
 expressly or implied, warrants this information to be accurate and
 disclaims all liability for its use.  Any person utilizing this
 document should seek competent professional advice to verify and
 assume responsibility for the suitability of this information to their
 particular situation.