SIGMA CHEMICAL CO -- 4-AMINOANTIPYRINE FREE BASE, A4383 -- 6505-00N092676 
=====================  Product Identification  =====================

Product ID:4-AMINOANTIPYRINE FREE BASE, A4383
MSDS Date:07/01/1999
FSC:6505
NIIN:00N092676
Status Code:A
=== Responsible Party ===
Company Name:SIGMA CHEMICAL CO
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Info Phone Num:314-771-5765
Emergency Phone Num:314-771-5765
CAGE:21076
=== Contractor Identification ===
Company Name:SIGMA CHEMICAL COMPANY
Address:3050 SPRUCE ST
Box:14508
City:ST LOUIS
State:MO
ZIP:63178
Country:US
Phone:314-771-5765
CAGE:21076

=============  Composition/Information on Ingredients  =============

Ingred Name:4-AMINOANTIPYRINE (FREE BASE)
CAS:83-07-8
RTECS #:CD2480000
= Wt:100.
Other REC Limits:N/K 
OSHA PEL:N/K 
OSHA STEL:N/K 
ACGIH TLV:N/K 
ACGIH STEL:N/K 

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED. MAY BE
    HARMFUL IF INHALED. MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    CAUSES EYE AND SKIN IRRITATION. MATERIAL IS IRRITATING TO MUCOUS
    MEMBRANES AND UPPER RESPIRATORY TR ACT. TO THE BEST OF
    MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL
    PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.

=======================  First Aid Measures  =======================

First Aid:EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT
    LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS
    AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. IF NOT
    BREATHING, GIVE AR TIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT,
    GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON
    IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
    REUSE.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
    APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

==================  Accidental Release Measures  ==================

Spill Release Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
    APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN
    A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE
    AREA AND WASH SPILL SI TE AFTER MATERIAL PICKUP IS COMPLETE.

======================	Handling and Storage  ======================

Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
    ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
    IRRITANT. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:RUBBER GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
    SHOWER .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:>108.C, 226.4F
M.P/F.P Text:108C - 110C
Appearance and Odor:YELLOW CRYSTALLINE POWDER.

=================  Stability and Reactivity Data  =================

STRONG OXIDIZING AGENTS, STRONG ACIDS, ACID CHLORIDES, ACID ANHYDRIDES.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
    DIOXIDE, NITROGEN OXIDES.

===================  Toxicological Information	===================

Toxicological Information:RTECS NUMBER: DC2480000 - ANTIPYRINE,
    4-AMINO-. TOXICITY DATA: ORL-RAT LD50: 1700 MG/KG; BCFAAI 117, 638,
    1978. IPR-RAT LD50: 1200 MG/KG; JPETAB 99, 171, 1950. ORL-MUS LD50:
    800 MG/KG; CCCCAK 47, 636,	1982. IPR-MUS LD50: 270 MG/KG; ARZNAD
    10, 820, 1960. TARGET ORGAN DATA: BEHAVIORAL (CONVULSIONS OR EFFECT
    ON SEIZURE THRESHOLD, EXCITEMENT). ONLY SELECTED REGISTRY OF TOXIC
    EFFECTS OF CHEMICAL SUBSTA NCES (RTECS) DATA IS PRESENTED HERE. SEE
    ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION.

=====================  Ecological Information  =====================

Ecological:DATA NOT YET AVAILABLE.

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
    SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
    AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
    ENVIRONMENTAL REGULATIONS.

===================  MSDS Transport Information  ===================

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
    INFORMATION.

=====================  Regulatory Information  =====================

Federal Regulatory Information:EUROPEAN INFORMATION: HARMFUL. R 22:
    HARMFUL IF SWALLOWED. R 36/37/38: IRRITATING TO EYES, RESPIRATORY
    SYSTEM AND SKIN. S 26: IN CASE OF CONTACT WITH EYES, RINSE
    IMMEDIATELY WITH PLENTY OF WATER AND S EEK MEDICAL ADVICE. S 36:
    WEAR SUITABLE PROTECTIVE CLOTHING. REVIEWS, STANDARDS, AND
    REGULATIONS: OEL=MAK. NOHS 1974: HZD 82277; NIS 4; TNF 114; NOS 3;
    TNE 1130. NOES 1983: HZD 82277; NIS 5; TNF 1080;  NOS 7; TNE 12808;
    TFE 9012. EPA GENETOX PROGRAM 1988, NEGATIVE: HYSTIDINE
    REVERSION-AMES TEST. EPA  TSCA SECTION 8 (B) CHEMICAL INVENTORY.
    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, DECEMBER 1998.
State Regulatory Information:

=======================  Other Information  =======================

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